The National Brain Appeal aims to transform the lives of the millions of people living with neurological and neuromuscular conditions.

They drive advancement by funding pioneering research, innovative treatments and world-class facilities – over and above what the NHS can provide.

"Williams Syndrome is a rare congenital disorder that occurs randomly and affects around one in 18,000 people in the UK. It is non-hereditary and causes distinctive facial characteristics and a wide range of learning difficulties. Infants often have delayed development and can develop physical and mental health problems, including anxiety and depression in later life."

Dreams Come True is a national charity with a mission to enrich the lives of children with a disability, serious illness or life-limiting condition by making their dreams come true. It is the only UK wish granting charity that supports children living in the highest areas of deprivation.

Whether it’s a UK family getaway for a young cancer patient, a specially adapted trike for a child with cerebral palsy or a tablet to help an autistic teenager develop their communication skills, each dream brings moments of magic and has a lasting impact for years to come.

With the cost-of-living crisis and soaring inflation, families are struggling to make ends meet. Especially those faced with extra costs due to having a child with additional needs.

Our vision is a world free from the fear of heart and circulatory diseases.

A world where fewer hearts stop without warning and all of us get more time with the people we love. Your support will power groundbreaking research to bring hope to families and keep hearts beating across the UK.

Cure Parkinson's is here for the cure. We are working with urgency to find new treatments to slow, stop and reverse Parkinson’s. We believe that collaboration between researchers, scientists, patients and funders is the key to accelerating promising treatments that will benefit people living with Parkinson’s.

Since 1984, we have been supporting children to ensure they have access to their education, to help maximise their life chances. We provide bespoke whole family support with and through schools to help understand and tackle barriers to good school attendance. We do this by building trust, resilience and skills across the whole family.

Children and families are at the centre of everything we do. Our ultimate goal is to make an effective, long-lasting impact in the lives of the children, young people, families and communities we serve by strengthening the bridge between home and school. 

We’re a charity that provides a unique team of expert doctors, paramedics and pilots who are dedicated to providing London with world-class medical care when a life is on the line.   

 When patients in London suffer life-threatening injury, only our teams can provide them with the help they need, performing complex medical procedures to give hope where others can’t.

The Salvation Army works at the heart of communities, offering friendship, practical help and support to some of the most disadvantaged people across the UK. Our work includes homelessness, modern slavery, poverty, addiction, support for children and families and older people who are lonely and isolated, and community-based work such as debt advice and unemployment. Motivated by a commitment to care for those who are vulnerable and marginalised, we strive to empower individuals and strengthen local communities.

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We fund the brilliant minds and bright ideas, putting change in sight for everyone impacted by vision loss. 

Together we will save sight, change lives.

Save the Rhino International is a UK-based charity working towards a future where all five rhino species thrive in the wild. Supporting and collaborating with expert conservationists, rangers, communities and organisations around the world. 

Through targeted funding and long-term partnerships, the charity helps to accelerate rhino population recovery by strengthening law enforcement and anti-poaching initiatives, disrupting organised crime networks linked to the illegal wildlife trade, and amplifying the resilience of critical rhino habitats. Save the Rhino International is committed to safeguarding the future of rhinos and their landscapes, and empowering the individuals that rely on them through conservation actions. 

Want to be a rhino champion? Join our rhino team for Santa in the City London! Put on a Santa suit (or a rhino costume!) and run, jog, or walk your way around a festive 4k route through central London. It’s the perfect way to kick off the holiday season and show your support for rhino conservation